Science2 weeks ago 6 min read
NAD+ precursors vs peptide 'energy' protocols: what the evidence says
Two popular approaches to 'cellular energy' compared head-to-head in the literature.
by Editorial team
The two approaches
NAD+ precursors (NR, NMN) aim to raise cellular NAD+ levels and support mitochondrial function.
Several peptide protocols (e.g. MOTS-c, SS-31) target mitochondrial function more directly.
What the evidence shows
NAD+ precursor trials show consistent NAD+ elevation but inconsistent functional benefits in healthy adults.
Peptide-based mitochondrial protocols have promising preclinical data but limited human evidence.
Picking carefully
Neither approach has earned the 'cellular energy' marketing claims attached to them.
Focus on sleep, training, and nutrition first; supplements and peptides are at best supportive.